Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
VPS38_ARATH | developmental stage | Strongly expressed in nascent leaves and, as leaves grow, progressively restricted to the vasculatures, leaves tips and hydathodes along leaves margins (PubMed:29897620). In roots, accumulates in the tips, vasculatures and lateral root initiation sites (PubMed:29897620). In flowers, present in anthers, pollen and pistils (PubMed:29897620). |
VPS38_ARATH | function | Dispensable for autophagy but essential for efficient targeting and degradation of biosynthetic and endocytic cargo to the vacuole (PubMed:29184027). Required for seedling development and plant growth as well as for seed storage proteins (SSPs) vacuolar trafficking (PubMed:29184027). Controls multiple aspects of development by affecting late endosome morphology and by regulating vacuolar and endocytic cargos (e.g PIN1 and PIN2) trafficking and distributions (e.g. polarity), thus influencing auxin transport orientation (PubMed:29184027, PubMed:29897620). |
VPS38_ARATH | subcellular location | Colocalizes with and mobilizes VPS29 at late endosomes, probably in a PI3K complex-dependent manner. |
VPS38_ARATH | tissue specificity | Predominantly expressed in the shoot apical meristem (SAM) and in the leaf vascular tissues (PubMed:29897620). Also observed in roots, pollen and flowers (PubMed:29897620). |
Function
Gene Ontology
cellular component | |
---|---|
phosphatidylinositol 3-kinase complex | ECO |
multivesicular body membrane | ECO |
cytosol | ECO |
endosome | ECO |
multivesicular body | ECO |
molecular function | |
retromer complex binding | ECO |
phosphatidylinositol 3-kinase catalytic subunit binding | ECO |
phosphatidylinositol 3-kinase binding | ECO |
biological process | |
regulation of auxin polar transport | ECO |
protein storage vacuole organization | ECO |
multivesicular body sorting pathway | ECO |
protein targeting to vacuole | ECO |
auxin-activated signaling pathway | ECO |