Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
EME1A_ARATH-2 EME1A_ARATH | function | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference. |
A0A1P8AYE0_ARATH EME1A_ARATH-2 EME1A_ARATH | similarity | Belongs to the EME1/MMS4 family. |
Function
Gene Ontology
cellular component | |
---|---|
Holliday junction resolvase complex | ECO |
nucleus | ECO |
molecular function | |
metal ion binding | ECO |
DNA binding | ECO |
endonuclease activity | ECO |
biological process | |
DNA recombination | ECO |
cell division | ECO |
meiotic cell cycle | ECO |
DNA repair | ECO |
Interactions
Interaction Network
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