Genomics
Overlapping Features
Genome features that overlap coordinates of this Gene
CDSs: 20, Exons: 13, Five Prime UTR: 1, mRNAs: 2, Three Prime UTR: 1, Transposable Elements: 2, Transposon Fragments: 2
Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
A0A1P8B0G7_ARATH Q9SIK4_ARATH | function | Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP. |
A0A1P8B0G7_ARATH Q9SIK4_ARATH | pathway | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1. |
A0A1P8B0G7_ARATH Q9SIK4_ARATH | similarity | In the C-terminal section; belongs to the thymidylate synthase family. |
A0A1P8B0G7_ARATH Q9SIK4_ARATH | similarity | In the N-terminal section; belongs to the dihydrofolate reductase family. |
Function
Gene Ontology
cellular component | |
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No terms in this category. | |
molecular function | |
thymidylate synthase activity | ECO |
dihydrofolate reductase activity | ECO |
biological process | |
one-carbon metabolic process | ECO |
dTMP biosynthetic process | ECO |
tetrahydrofolate biosynthetic process | ECO |
methylation | ECO |