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Gene : AT2G21550 A. thaliana

DB identifier  ? AT2G21550 Secondary Identifier  ? locus:2049389
Brief Description  Bifunctional dihydrofolate reductase/thymidylate synthase
TAIR Computational Description  Bifunctional dihydrofolate reductase/thymidylate synthase;(source:Araport11)
TAIR Curator Summary  One of three DRTS genes, this is the most divergent one.THY3/DRTS3 is preferentially expressed in the shoot apex, stipules and root caps.
TAIR Short Description  Bifunctional dihydrofolate reductase/thymidylate synthase
TAIR Aliases  DHFR-TS3, DRTS3

2 Gene Rifs

1 Organism

6 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3289  
Location: Chr2:9226917-9230205

Gene models - AT2G21550 AT2G21550

? Gene models

Transcripts: 2  Exons: 20  Introns: 18 

Overlapping Features

? Genome features that overlap coordinates of this Gene

15 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
A0A1P8B0G7_ARATH Q9SIK4_ARATH function Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
A0A1P8B0G7_ARATH Q9SIK4_ARATH pathway Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
A0A1P8B0G7_ARATH Q9SIK4_ARATH similarity In the C-terminal section; belongs to the thymidylate synthase family.
A0A1P8B0G7_ARATH Q9SIK4_ARATH similarity In the N-terminal section; belongs to the dihydrofolate reductase family.

2 Proteins

Function

Gene Ontology

cellular component
No terms in this category.
molecular function
thymidylate synthase activity  ? ECO  
dihydrofolate reductase activity  ? ECO  
biological process
one-carbon metabolic process  ? ECO  
dTMP biosynthetic process  ? ECO  
tetrahydrofolate biosynthetic process  ? ECO  
methylation  ? ECO  

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets