Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
ERO1_ARATH | function | Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity). |
ERO1_ARATH | similarity | Belongs to the EROs family. |
Function
Gene Ontology
cellular component | |
---|---|
endoplasmic reticulum | ECO |
endoplasmic reticulum membrane | ECO |
molecular function | |
protein-disulfide reductase activity | ECO |
FAD binding | ECO |
thiol oxidase activity | ECO |
biological process | |
protein folding in endoplasmic reticulum | ECO |
Interactions
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