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Gene : ERO1 A. thaliana

DB identifier  ? AT1G72280 Secondary Identifier  ? locus:2207031
Name  ? endoplasmic reticulum oxidoreductins 1 Brief Description  endoplasmic reticulum oxidoreductins 1
TAIR Computational Description  endoplasmic reticulum oxidoreductins 1;(source:Araport11)
TAIR Curator Summary  Encodes an oxidoreductin required for oxidative protein folding in the ER and exists in two distinct oxidized isoforms (Ox1 and Ox2), which are determined by the formation or breakage of the putative regulatory disulfide. AtERO1 is mainly present in the Ox1 redox state.
TAIR Short Description  endoplasmic reticulum oxidoreductins 1
TAIR Aliases  AERO1, ERO1

1 Gene Rifs

1 Organism

9 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2868  
Location: Chr1:27211821-27214688 reverse strand

Gene models - ERO1 AT1G72280

? Gene models

Transcripts: 1  Exons: 9  Introns: 8 

Overlapping Features

? Genome features that overlap coordinates of this Gene

10 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
ERO1_ARATH function Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
ERO1_ARATH similarity Belongs to the EROs family.

1 Proteins

Function

Gene Ontology

cellular component
endoplasmic reticulum  ? ECO  
endoplasmic reticulum membrane  ? ECO  
molecular function
protein-disulfide reductase activity  ? ECO  
FAD binding  ? ECO  
thiol oxidase activity  ? ECO  
biological process
protein folding in endoplasmic reticulum  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets