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Gene : WIT2 A. thaliana

DB identifier  ? AT1G68910 Secondary Identifier  ? locus:2205470
Name  ? WPP domain-interacting protein 2 Brief Description  WPP domain-interacting protein 2
TAIR Computational Description  WPP domain-interacting protein 2;(source:Araport11)
TAIR Curator Summary  Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
TAIR Short Description  WPP domain-interacting protein 2
TAIR Aliases  WIT2

1 Gene Rifs

1 Organism

10 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3232  
Location: Chr1:25908046-25911277 reverse strand

Gene models - WIT2 AT1G68910

? Gene models

Transcripts: 3  Exons: 15  Introns: 12 

Overlapping Features

? Genome features that overlap coordinates of this Gene

12 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
WIT2_ARATH-2 WIT2_ARATH function Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips (PubMed:18591351). Plays a role in nuclear shape determination (PubMed:25759303). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).
WIT2_ARATH-2 WIT2_ARATH tissue specificity Ubiquitous.

2 Proteins

Function

Gene Ontology

cellular component
membrane  ? ECO  
molecular function
myosin XI tail binding  ? ECO  
biological process
regulation of establishment or maintenance of cell polarity regulating cell shape  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets