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Gene : 4CL1 A. thaliana

DB identifier  ? AT1G51680 Secondary Identifier  ? locus:2017602
Name  ? 4-coumarate:CoA ligase 1 Brief Description  4-coumarate:CoA ligase 1
TAIR Computational Description  4-coumarate:CoA ligase 1;(source:Araport11)
TAIR Curator Summary  encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. In addition to 4-coumarate, it also converts ferulate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, ferulic acid, caffeic acid and 5-OH-ferulic acid. At4CL1 was unable to use sinapic acid as substrate.
TAIR Short Description  4-coumarate:CoA ligase 1
TAIR Aliases  4CL.1, 4CL1, AT4CL1

1 Gene Rifs

1 Organism

36 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2992  
Location: Chr1:19158746-19161737 reverse strand

Gene models - 4CL1 AT1G51680

? Gene models

Transcripts: 3  Exons: 10  Introns: 7 

Overlapping Features

? Genome features that overlap coordinates of this Gene

11 Child Features

0 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
4CL1_ARATH-2 4CL1_ARATH function Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics (PubMed:10417722). Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioesters (By similarity).
4CL1_ARATH-2 4CL1_ARATH pathway Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2.
4CL1_ARATH-2 A8MS69_ARATH 4CL1_ARATH similarity Belongs to the ATP-dependent AMP-binding enzyme family.
4CL1_ARATH-2 4CL1_ARATH tissue specificity Preferentially expressed in roots, bolting stems and siliques. Also detected in leaves.

3 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
molecular function
ATP binding  ? ECO  
(E)-caffeate-CoA ligase activity  ? ECO  
4-coumarate-CoA ligase activity  ? ECO  
biological process
phenylpropanoid metabolic process  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets