Toll-Interleukin-Resistance (TIR) domain family protein
TAIR Computational Description
Toll-Interleukin-Resistance (TIR) domain family protein;(source:Araport11)
TAIR Curator Summary
RBA1 variant in Ag0 background is a TIR-only receptor protein that binds to the bacterial type III effector protein HopBA. The Col-0 variant, which is not expressed, is likely a psuedogene and more highly methylated than the Ag0 variant which is expressed.
TAIR Short Description
Toll-Interleukin-Resistance (TIR) domain family protein
Disease resistance (R) protein that specifically recognizes the HopBA1 type III effector protein from P.syringae, and triggers cell death (PubMed:28137883). Acts as a NAD(+) hydrolase (NADase): in response to pathogen-recognition, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439793). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown (PubMed:31439793). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:31439793).