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Gene : AT1G26800 A. thaliana

DB identifier  ? AT1G26800 Secondary Identifier  ? locus:2200610
Brief Description  RING/U-box superfamily protein
TAIR Computational Description  RING/U-box superfamily protein;(source:Araport11)
TAIR Curator Summary  MPSR1 is cytoplasmic E3 ligase that senses misfolded proteins independently of chaperones and targets those proteins for degradation via the 26S proteasome. Involved in the regulation of the homeostasis of sensor NLR immune receptors.
TAIR Short Description  RING/U-box superfamily protein
TAIR Aliases  MPSR1, SNIPER2

0 Gene Rifs

1 Organism

8 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 1371  
Location: Chr1:9285025-9286395 reverse strand

Gene models - AT1G26800 AT1G26800

? Gene models

Transcripts: 1  Exons: 1 

Overlapping Features

? Genome features that overlap coordinates of this Gene

2 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
MPSR1_ARATH function E3 ubiquitin-protein ligase involved in protein quality control (PQC) under proteotoxic stress. Is essential to plant survival under proteotoxic stress. Functions by removing damaged proteins before they form cytotoxic aggregates. Recognizes misfolded proteins selectively and tethers polyubiquitin chains to the proteins directly for subsequent degradation by the 26S proteasome pathway. Targets misfolded proteins independently of cytoplasmic chaperones. Associates with the 26S proteasome and sustains the structural integrity of the proteasome complex at the initial stage of proteotoxic stress. Under normal conditions, MPSR1 becomes highly unstable by its autoubiquitination activity and is stabilized during proteotoxic stress by conjugating ubiquitins on misfolded proteins.

1 Proteins

Function

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets