Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
MPSR1_ARATH | function | E3 ubiquitin-protein ligase involved in protein quality control (PQC) under proteotoxic stress. Is essential to plant survival under proteotoxic stress. Functions by removing damaged proteins before they form cytotoxic aggregates. Recognizes misfolded proteins selectively and tethers polyubiquitin chains to the proteins directly for subsequent degradation by the 26S proteasome pathway. Targets misfolded proteins independently of cytoplasmic chaperones. Associates with the 26S proteasome and sustains the structural integrity of the proteasome complex at the initial stage of proteotoxic stress. Under normal conditions, MPSR1 becomes highly unstable by its autoubiquitination activity and is stabilized during proteotoxic stress by conjugating ubiquitins on misfolded proteins. |
Function
Gene Ontology
cellular component | |
---|---|
cytosol | ECO |
cytoplasm | ECO |
molecular function | |
ubiquitin protein ligase activity | ECO |
misfolded protein binding | ECO |
metal ion binding | ECO |
biological process | |
protein polyubiquitination | ECO |
cellular response to misfolded protein | ECO |
protein autoubiquitination | ECO |
cellular response to hypoxia | ECO |
regulation of protein complex stability | ECO |
cytoplasm protein quality control by the ubiquitin-proteasome system | ECO |
Interactions
Interaction Network
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