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Gene : AT1G20110 A. thaliana

DB identifier  ? AT1G20110 Secondary Identifier  ? locus:2198646
Brief Description  RING/FYVE/PHD zinc finger superfamily protein
TAIR Computational Description  RING/FYVE/PHD zinc finger superfamily protein;(source:Araport11)
TAIR Curator Summary  Encodes a protein that is localized to the peripheral membrane of late endosomal compartments. Involved in the regulation of mulitivesicular/prevacuolar compartment protein sorting. Loss of function mutations are embryo lethal. Regulates IRT1-dependent metal transport and metal homeostasis. The mRNA is cell-to-cell mobile.
TAIR Short Description  RING/FYVE/PHD zinc finger superfamily protein
TAIR Aliases  FREE1, FYVE1, PDE330

11 Gene Rifs

1 Organism

32 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3707  
Location: Chr1:6971424-6975130

Gene models - AT1G20110 AT1G20110

? Gene models

Transcripts: 1  Exons: 10  Introns: 9 

Overlapping Features

? Genome features that overlap coordinates of this Gene

11 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
FREE1_ARATH function Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth (PubMed:25438943). Required for the formation of intra-luminal vesicles (ILVs)in MVBs (PubMed:25438943). Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin (PubMed:24843126, PubMed:25438943). Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain (PubMed:24843126). Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis (PubMed:25624505, PubMed:25699591). ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins (PubMed:27495812). Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4 (PubMed:27495812). Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway (PubMed:27495812). In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import (PubMed:30962512). In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway (PubMed:30962512). Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway (PubMed:32540007).
FREE1_ARATH subcellular location In response to abscisic acid (ABA), SnRK2 kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import.
FREE1_ARATH tissue specificity Ubiquitous. Lowest expression in mature seeds.

1 Proteins

Function

Interactions

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Expression

eFP Visualization

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Co-expression

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Data Source: ATTED-II
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LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets