Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
FREE1_ARATH | function | Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth (PubMed:25438943). Required for the formation of intra-luminal vesicles (ILVs)in MVBs (PubMed:25438943). Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin (PubMed:24843126, PubMed:25438943). Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain (PubMed:24843126). Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis (PubMed:25624505, PubMed:25699591). ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins (PubMed:27495812). Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4 (PubMed:27495812). Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway (PubMed:27495812). In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import (PubMed:30962512). In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway (PubMed:30962512). Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway (PubMed:32540007). |
FREE1_ARATH | subcellular location | In response to abscisic acid (ABA), SnRK2 kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import. |
FREE1_ARATH | tissue specificity | Ubiquitous. Lowest expression in mature seeds. |
Function
Gene Ontology
cellular component | |
---|---|
late endosome membrane | ECO |
ESCRT I complex | ECO |
nucleus | ECO |
multivesicular body | ECO |
molecular function | |
ubiquitin binding | ECO |
mRNA binding | ECO |
metal ion binding | ECO |
biological process | |
negative regulation of abscisic acid-activated signaling pathway | ECO |
abscisic acid-activated signaling pathway | ECO |
protein transport | ECO |
intralumenal vesicle formation | ECO |
multivesicular body assembly | ECO |
Interactions
Interaction Network
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