Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
TFB5_ARATH | function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
A0A1P8AR18_ARATH | function | In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. |
TFB5_ARATH A0A1P8AR18_ARATH | similarity | Belongs to the TFB5 family. |
Function
Gene Ontology
cellular component | |
---|---|
transcription factor TFIIH holo complex | ECO |
transcription factor TFIIH core complex | ECO |
molecular function | |
No terms in this category. | |
biological process | |
transcription by RNA polymerase II | ECO |
nucleotide-excision repair, preincision complex assembly | ECO |
transcription initiation at RNA polymerase II promoter | ECO |
Interactions
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