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Gene : PYM A. thaliana

DB identifier  ? AT1G11400 Secondary Identifier  ? locus:2200116
Name  ? partner of Y14-MAGO Brief Description  partner of Y14-MAGO
TAIR Computational Description  partner of Y14-MAGO;(source:Araport11)
TAIR Curator Summary  The PYM gene encodes a protein capable of interacting with MAGO, and Y14, whose orthologs form part of the exon junction complex in animal cells. In vitro binding assays indicate that PYM can bind to MAGO and Y14 either individually, or when they are together. But, MAGO-Y14-PYM ternary complexes are difficult to detect in vivo in Arabidopsis based on pull-down experiments. However there is some evidence for a weak association in Arabidopsis flowers. PYM appears primarily cytoplasmic, but it also seems to into the nucleus at times. Its nuclear localization signal has not been rigorously defined, but there is evidence for a nuclear export signal between amino acids 171-205 in the C-terminus.
TAIR Short Description  partner of Y14-MAGO
TAIR Aliases  PYM

1 Gene Rifs

1 Organism

7 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3525  
Location: Chr1:3837694-3841218

Gene models - PYM AT1G11400

? Gene models

Transcripts: 6  Exons: 32  Introns: 26 

Overlapping Features

? Genome features that overlap coordinates of this Gene

21 Child Features

0 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
PYM1_ARATH function Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs (By similarity). Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes. In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression (PubMed:21676911).
PYM1_ARATH similarity Belongs to the pym family.
PYM1_ARATH subcellular location Can shuttle between the nucleus and the cytoplasm, but is mainly cytoplasmic.
PYM1_ARATH tissue specificity Expressed in root and shoot meristems, cotyledons, vascular tissues of leaves, receptacle of flowers and siliques, and pollen grains.

1 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
nucleolus  ? ECO  
exon-exon junction complex  ? ECO  
nucleoplasm  ? ECO  
molecular function
RNA binding  ? ECO  
biological process
positive regulation of gene expression  ? ECO  
mRNA transport  ? ECO  
exon-exon junction complex disassembly  ? ECO  
regulation of translation  ? ECO  
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  ? ECO  

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets