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Gene : emb2411 A. thaliana

DB identifier  ? AT1G08840 Secondary Identifier  ? locus:2025610
Name  ? embryo defective 2411 Brief Description  DNA replication helicase
TAIR Computational Description  DNA replication helicase;(source:Araport11)
TAIR Curator Summary  Encodes a homolog of human and yeast DNA2. Mutants have increased sensitivity to DNA damage stress.
TAIR Short Description  DNA replication helicase, putative
TAIR Aliases  emb2411, JHS1

1 Gene Rifs

1 Organism

7 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 9751  
Location: Chr1:2829105-2838855 reverse strand

Gene models - emb2411 AT1G08840

? Gene models

Transcripts: 5  Exons: 168  Introns: 163 

Overlapping Features

? Genome features that overlap coordinates of this Gene

49 Child Features

0 Cross References

0 Downstream Intergenic Region

0 Located Features

0 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
JHS1_ARATH JHS1_ARATH-3 JHS1_ARATH-2 function Essential protein required during embryogenesis (PubMed:15266054). Key enzyme involved in DNA replication and damage repair, shoot apical meristem (SAM) maintenance, and development (PubMed:26951435). Involved in Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement (By similarity).
F4HXR5_ARATH A0A1P8ASU0_ARATH A0A5S9TCQ8_ARATH function Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
JHS1_ARATH F4HXR5_ARATH JHS1_ARATH-3 JHS1_ARATH-2 A0A1P8ASU0_ARATH A0A5S9TCQ8_ARATH similarity Belongs to the DNA2/NAM7 helicase family.
JHS1_ARATH JHS1_ARATH-3 JHS1_ARATH-2 subcellular location Localized to nuclear foci in response to DNA damage.
JHS1_ARATH JHS1_ARATH-3 JHS1_ARATH-2 tissue specificity Strongly expressed in meristems, including both root and shoot apical meristems (RAM and SAM) (PubMed:26951435). Also present in the vasculature and in young floral tissues (PubMed:26951435).

6 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
chromosome  ? ECO  
nucleus  ? ECO  
molecular function
5'-flap endonuclease activity  ? ECO  
4 iron, 4 sulfur cluster binding  ? ECO  
metal ion binding  ? ECO  
RNA binding  ? ECO  
DNA binding  ? ECO  
single-stranded DNA helicase activity  ? ECO  
ATP hydrolysis activity  ? ECO  
ATP binding  ? ECO  
biological process
DNA replication  ? ECO  
meristem maintenance  ? ECO  
replication fork reversal  ? ECO  
DNA damage response  ? ECO  
DNA repair  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets