Genomics
Overlapping Features
Genome features that overlap coordinates of this Gene
Antisense lncRNA: 1, CDSs: 15, Exons: 10, Five Prime UTR: 1, Genes: 2, mRNAs: 4, Three Prime UTRs: 2
Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
NLA_ARATH-2 NLA_ARATH | function | E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination (PubMed:17355433). Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation (PubMed:18753285). May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis (PubMed:18753285). Involved in defense response (PubMed:35839945). May act as negative regulator of resistance to the necrotrophic fungal pathogen Plectosphaerella cucumerina by modulating the accumulation of the phytoalexin camalexin and the salicylic acid- and jasmonate- dependent defense pathways (PubMed:35839945). Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis (PubMed:17355433, PubMed:18552353). Involved in the regulation of inorganic phosphate (Pi) homeostasis in a nitrate-dependent fashion (PubMed:21455488). Directs the ubiquitination and subsequent degradation of the plasma membrane-localized inorganic phosphate transporters PHT1-1 and PHT1-4, to maintain phosphate homeostasis (PubMed:24122828). The ubiquitination of PHTs triggers their clathrin-dependent endocytosis and trafficking to the vacuole through the endosomal pathway for degradation (PubMed:24122828). Functions cooperatively with UBC24/PHO2 to regulate the abundance of PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments (PubMed:24122828). Regulates Pi homeostasis by mediating, cooperatively with UBC24/PHO2, polyubiquitination of PHT1-4 and its targeting for degradation (PubMed:24474629). Directs the polyubiquitination and subsequent degradation of the plasma membrane-localized nitrate transporter NPF2.13/NRT1.7, to help plants to adapt to nitrogen deficiency by regulating the source-to-sink remobilization of nitrate (PubMed:28032637). Regulates leaf senescence during nitrogen deficiency by mediating, cooperatively with UBC24/PHO2, polyubiquitination of NAC92/ORE1 and its targeting for degradation (PubMed:30374089). |
NLA_ARATH-2 A0A1P8AR01_ARATH NLA_ARATH | pathway | Protein modification; protein ubiquitination. |
NLA_ARATH-2 NLA_ARATH | subcellular location | Localizes at the plasma membrane, where it interacts with PHT1-1 and PHT1-4 (PubMed:24122828). Localizes at the plasma membrane, where it interacts with NPF2.13/NRT1.7 (PubMed:28032637). Localizes in the nucleus, where it interacts with NAC92/ORE1 (PubMed:30374089). |
NLA_ARATH-2 NLA_ARATH | tissue specificity | High expression in roots and stems, medium in seedlings, flowers, rosette and cauline leaves, and very low in siliques. Detected in cotyledons, hypocotyls, pedicel, receptacle, pistil, sepal, filament of stamen and at the two ends of developing siliques. |
Function
Gene Ontology
cellular component | |
---|---|
plasma membrane | ECO |
nucleus | ECO |
nuclear speck | ECO |
molecular function | |
ubiquitin-protein transferase activity | ECO |
metal ion binding | ECO |
biological process | |
protein ubiquitination | ECO |
plant-type hypersensitive response | ECO |
regulation of salicylic acid metabolic process | ECO |
response to salicylic acid | ECO |
defense response to bacterium | ECO |
response to nitrate | ECO |
response to benzoic acid | ECO |
systemic acquired resistance | ECO |
salicylic acid biosynthetic process | ECO |
Interactions
Interaction Network
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