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Gene : NLA A. thaliana

DB identifier  ? AT1G02860 Secondary Identifier  ? locus:2024675
Name  ? nitrogen limitation adaptation Brief Description  SPX (SYG1/Pho81/XPR1) domain-containing protein
TAIR Computational Description  SPX (SYG1/Pho81/XPR1) domain-containing protein;(source:Araport11)
TAIR Curator Summary  Encodes a ubiquitin E3 ligase with RING and SPX domains that is involved in mediating immune responses and mediates degradation of PHT1s at plasma membranes. Targeted by MIR827. Ubiquitinates PHT1;3, PHT1;2, PHT1;1/AtPT1 and PHT1;4/AtPT2.
TAIR Short Description  SPX (SYG1/Pho81/XPR1) domain-containing protein
TAIR Aliases  BAH1, NLA, SYG1

10 Gene Rifs

1 Organism

21 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2119  
Location: Chr1:635144-637262

Gene models - NLA AT1G02860

? Gene models

Transcripts: 3  Exons: 15  Introns: 12 

Overlapping Features

? Genome features that overlap coordinates of this Gene

11 Child Features

0 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
NLA_ARATH-2 NLA_ARATH function E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination (PubMed:17355433). Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation (PubMed:18753285). May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis (PubMed:18753285). Involved in defense response (PubMed:35839945). May act as negative regulator of resistance to the necrotrophic fungal pathogen Plectosphaerella cucumerina by modulating the accumulation of the phytoalexin camalexin and the salicylic acid- and jasmonate- dependent defense pathways (PubMed:35839945). Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis (PubMed:17355433, PubMed:18552353). Involved in the regulation of inorganic phosphate (Pi) homeostasis in a nitrate-dependent fashion (PubMed:21455488). Directs the ubiquitination and subsequent degradation of the plasma membrane-localized inorganic phosphate transporters PHT1-1 and PHT1-4, to maintain phosphate homeostasis (PubMed:24122828). The ubiquitination of PHTs triggers their clathrin-dependent endocytosis and trafficking to the vacuole through the endosomal pathway for degradation (PubMed:24122828). Functions cooperatively with UBC24/PHO2 to regulate the abundance of PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments (PubMed:24122828). Regulates Pi homeostasis by mediating, cooperatively with UBC24/PHO2, polyubiquitination of PHT1-4 and its targeting for degradation (PubMed:24474629). Directs the polyubiquitination and subsequent degradation of the plasma membrane-localized nitrate transporter NPF2.13/NRT1.7, to help plants to adapt to nitrogen deficiency by regulating the source-to-sink remobilization of nitrate (PubMed:28032637). Regulates leaf senescence during nitrogen deficiency by mediating, cooperatively with UBC24/PHO2, polyubiquitination of NAC92/ORE1 and its targeting for degradation (PubMed:30374089).
NLA_ARATH-2 A0A1P8AR01_ARATH NLA_ARATH pathway Protein modification; protein ubiquitination.
NLA_ARATH-2 NLA_ARATH subcellular location Localizes at the plasma membrane, where it interacts with PHT1-1 and PHT1-4 (PubMed:24122828). Localizes at the plasma membrane, where it interacts with NPF2.13/NRT1.7 (PubMed:28032637). Localizes in the nucleus, where it interacts with NAC92/ORE1 (PubMed:30374089).
NLA_ARATH-2 NLA_ARATH tissue specificity High expression in roots and stems, medium in seedlings, flowers, rosette and cauline leaves, and very low in siliques. Detected in cotyledons, hypocotyls, pedicel, receptacle, pistil, sepal, filament of stamen and at the two ends of developing siliques.

3 Proteins

Function

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets