Encodes a protein containing Leu-rich repeats and a degenerate F-box motif. Associates with AtCUL1, AtRbx1, and the Skp1-like proteins ASK1 and ASK2 to assemble SCF COI1 ubiquitin-ligase complexes in planta. A single amino acid substitution in the F-box motif of COI1 abolishes the formation of the SCF(COI1) complexes and results in loss of the JA response. Required for wound- and jasmonates-induced transcriptional regulation. Amino acid mutations in COI1 distinctively affect jasmonate-regulated male fertility.CFA-Ile, CFA-Leu, CFA-Val, CFA-Met and CFA-Ala could not inhibit the root length and restoration of fertility in coi1-1 mutants.
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