Type |
Details |
Score |
Protein Domain |
|
•
•
•
•
•
|
GeneRIF (Gene Reference into Function) |
Annotation: |
By influencing the levels of reactive oxygen species, AtOXR2 improves the efficiency of photosynthesis and elicits basal tolerance to environmental challenges that increase oxidative stress, allowing improved plant growth and biomass production. |
Organism: |
A. thaliana |
Gene: |
AT2G05590 |
PubMed Id: |
30945737 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Gene |
Length: |
3891
|
Chromosome Location: |
Chr1: 23808835-23812725 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
Uncharacterized protein family (UPF0016);(source:Araport11) |
TAIR Curator Summary: |
Encodes an integral thylakoid membrane protein that is required for normal operation of oxygen-evolving complex (as evidenced by oxygen evolution rates) and for manganese incorporation. PAM71 belongs to a small gene family in Arabidopsis comprising five members. PAM71 is well conserved in the green lineage and shares homology with putative Ca2+/H+ exchangers from yeast (Saccharomyces cerevisiae) (GDT1) and human (Homo sapiens) (TMEM165). |
TAIR Short Description: |
Uncharacterized protein family (UPF0016) |
TAIR Aliases: |
BICAT1, CCHA1, PAM71 |
|
•
•
•
•
•
|
Gene |
Length: |
1773
|
Chromosome Location: |
Chr5: 25526509-25528281 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
NAC domain containing protein 102;(source:Araport11) |
TAIR Curator Summary: |
Encodes a member of the NAC family of transcription factors. ANAC102 appears to have a role in mediating response to low oxygen stress (hypoxia) in germinating seedlings. Its expression can be induced by beta-cyclocitral, an oxidized by-product of beta-carotene generated in the chloroplasts, mediates a protective retrograde response that lowers the levels of toxic peroxides and carbonyls, limiting damage to intracellular components. |
TAIR Short Description: |
NAC domain containing protein 102 |
TAIR Aliases: |
ANAC102, NAC102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin S |
Title: |
Expression of γ-tocopherol methyltransferase in chloroplasts results in massive proliferation of the inner envelope membrane and decreases susceptibility to salt and metal-induced oxidative stresses by reducing reactive oxygen species. |
Year: |
2014 |
Journal: |
Plant Biotechnol J |
Volume: |
12 |
Pages: |
1274-85 |
|
•
•
•
•
•
|
Ontology Term |
Description: |
Protein involved in hypersensitive response, a complex and early defense response that causes necrosis and cell death to restrict the growth of a pathogen. Local and systemic biochemical changes include generation of active oxygen species (oxidative burst), cell death, overproduction of lignin-related materials, and the induction of certain proteins such as pathogen related (PR) proteins |
|
•
•
•
•
•
|
GO Term |
Description: |
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
|
•
•
•
•
•
|
GO Term |
Description: |
Binding to oxygen (O2). |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
GO Term |
Description: |
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
|
•
•
•
•
•
|
GO Term |
Description: |
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Gene |
Length: |
1722
|
Chromosome Location: |
Chr1: 8398115-8399836 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
Oxidoreductase, zinc-binding dehydrogenase family protein;(source:Araport11) |
TAIR Curator Summary: |
AOR is an alkenal/one oxidoreductase that acts on compounds with unsaturated alpha,beta-carbonyls. The activity of this enzyme with a number of substrates, including acrolein and 3-buten-2-one, was demonstrated in vitro using a truncated form of the protein that lacked approximately 80 of the first amino acids. This protein appears to localize to the chloroplast where it likely helps to maintain the photosynthetic process by detoxifying reactive carbonyls formed during lipid peroxidation. |
TAIR Short Description: |
Oxidoreductase, zinc-binding dehydrogenase family protein |
TAIR Aliases: |
AOR |
|
•
•
•
•
•
|
Gene |
Length: |
1837
|
Chromosome Location: |
Chr1: 1703002-1704838 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
Uridine diphosphate glycosyltransferase 74E2;(source:Araport11) |
TAIR Curator Summary: |
Encodes a UDP-glucosyltransferase, UGT74E2, that acts on IBA (indole-3-butyric acid) and affects auxin homeostasis. The transcript and protein levels of this enzyme are strongly induced by H2O2 and may allow integration of ROS (reactive oxygen species) and auxin signaling. This enzyme can also transfer glycosyl groups to several compounds related to the explosive TNT when this synthetic compound is taken up from the environment. |
TAIR Short Description: |
Uridine diphosphate glycosyltransferase 74E2 |
TAIR Aliases: |
UGT74E2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura S |
Title: |
Protein phosphorylation is a prerequisite for the Ca2+-dependent activation of Arabidopsis NADPH oxidases and may function as a trigger for the positive feedback regulation of Ca2+ and reactive oxygen species. |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Volume: |
1823 |
Pages: |
398-405 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Gene |
Length: |
2427
|
Chromosome Location: |
Chr2: 18297878-18300304 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
repressor of lrx1;(source:Araport11) |
TAIR Curator Summary: |
Encodes ROL5, a repressor of lrx1 mutants that develop aberrant root hairs. ROL5 is a homolog of yeast Ncs6p that affects TOR signaling. The target of rapamycin (TOR) pathway is a major regulator of cell growth in eukaryotes, and inhibition of this pathway by rapamycin reduces cell growth. ROL5 might function as a mitochondrial component of the TOR pathway that influences the plant's response to ROS (reactive oxygen species). |
TAIR Short Description: |
repressor of lrx1 |
TAIR Aliases: |
ROL5 |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Gene |
Length: |
1645
|
Chromosome Location: |
Chr3: 22662849-22664493 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
NAD(P)-binding Rossmann-fold superfamily protein;(source:Araport11) |
TAIR Curator Summary: |
CytADR/SDR1 is an aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on alpha,beta-unsaturated aldehydes with more than 5 carbons in vitro. It can also act on menthone and neomenthol in vitro, but these do not represent likely endogenous activities of this enzyme in planta. GFP-tagged CytADR appears to localize to the cytosol where it likely plays a role in detoxifying reactive carbonyls. sdr1 mutants have altered responses to pathogens. The mRNA is cell-to-cell mobile. |
TAIR Short Description: |
NAD(P)-binding Rossmann-fold superfamily protein |
TAIR Aliases: |
SDR1 |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that modulates the frequency, rate or extent of oxygen metabolic process. |
|
•
•
•
•
•
|
Gene |
Length: |
1696
|
Chromosome Location: |
Chr1: 20458952-20460647 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
NAD(P)-binding Rossmann-fold superfamily protein;(source:Araport11) |
TAIR Curator Summary: |
ChlADR is an aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons in vitro. The N-terminal region of this protein directs GFP to the chloroplast where where ChlADR likely helps to maintain the photosynthetic process by detoxifying reactive carbonyls formed during lipid peroxidation. In addition, this enzyme can also reduce cis-3-hexenal, a major plant volatile compound that contributes to green leaf odor, as well as methylglyoxal in vitro. |
TAIR Short Description: |
NAD(P)-binding Rossmann-fold superfamily protein |
TAIR Aliases: |
ChlADR |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
oxygen free radical metabolism |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
iron(II): oxygen oxidoreductase activity |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating) |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
regulation of oxygen metabolism |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
diatomic oxygen metabolic process |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
cellular response to oxygen |
Type: |
synonym |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Publication |
First Author: |
Spyrakis F |
Title: |
Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport. |
Year: |
2011 |
Journal: |
IUBMB Life |
Volume: |
63 |
Pages: |
355-62 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Gene |
Length: |
1435
|
Chromosome Location: |
Chr3: 1035238-1036672 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
NAD(P)-binding Rossmann-fold superfamily protein;(source:Araport11) |
TAIR Curator Summary: |
ChlADR is an aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons in vitro. The N-terminal region of this protein directs GFP to the chloroplast where where ChlADR likely helps to maintain the photosynthetic process by detoxifying reactive carbonyls formed during lipid peroxidation. In addition, this enzyme can also reduce cis-3-hexenal, a major plant volatile compound that contributes to green leaf odor, as well as methylglyoxal in vitro. Involved in higher growth rates under elevated CO2 conditions. |
TAIR Short Description: |
NAD(P)-binding Rossmann-fold superfamily protein |
TAIR Aliases: |
ChlADR |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Interaction Experiment |
Name: |
Schmidt HB (2015) |
Description: |
Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. |
|
•
•
•
•
•
|
Publication |
First Author: |
Poole RK |
Title: |
Reactions of the Escherichia coli flavohaemoglobin (Hmp) with oxygen and reduced nicotinamide adenine dinucleotide: evidence for oxygen switching of flavin oxidoreduction and a mechanism for oxygen sensing. |
Year: |
1994 |
Journal: |
Proc Biol Sci |
Volume: |
255 |
Pages: |
251-8 |
|
•
•
•
•
•
|
Gene |
Length: |
2048
|
Chromosome Location: |
Chr5: 23683784-23685831 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828);(source:Araport11) |
TAIR Curator Summary: |
Belongs to a large family of plant-specific genes of unknown function. Involved in resistance to the powdery mildew species Erysiphe cichoracearum and Erysiphe orontii, but not to the unrelated pathogens Pseudomonas syringae or Peronospora parasitica. A member of the TBL (TRICHOME BIREFRINGENCE-LIKE) gene family containing a plant-specific DUF231 (domain of unknown function) domain. TBL gene family has 46 members, two of which (TBR/AT5G06700 and TBL3/AT5G01360) have been shown to be involved in the synthesis and deposition of secondary wall cellulose, presumably by influencing the esterification state of pectic polymers. A nomenclature for this gene family has been proposed (Volker Bischoff & Wolf Scheible, 2010, personal communication). |
TAIR Short Description: |
Plant protein of unknown function (DUF828) |
TAIR Aliases: |
PMR5, TBL44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bailey-Serres J |
Title: |
Making sense of low oxygen sensing. |
Year: |
2012 |
Journal: |
Trends Plant Sci |
Volume: |
17 |
Pages: |
129-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flors C |
Title: |
Imaging the production of singlet oxygen in vivo using a new fluorescent sensor, Singlet Oxygen Sensor Green. |
Year: |
2006 |
Journal: |
J Exp Bot |
Volume: |
57 |
Pages: |
1725-34 |
|
•
•
•
•
•
|
Ontology Term |
Description: |
Enzymes that reduce molecular oxygen by incorporating one oxygen atom into its substrate and the other one in water |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. |
|
•
•
•
•
•
|
GO Term |
Description: |
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
|
•
•
•
•
•
|
GO Term |
Description: |
Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bailey CJ |
Title: |
The reactive serine residue of epidermolytic toxin A. |
Year: |
1990 |
Journal: |
Biochem J |
Volume: |
269 |
Pages: |
535-7 |
|
•
•
•
•
•
|
GO Term |
Description: |
The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. |
|
•
•
•
•
•
|
GO Term |
Description: |
Binding to oxygen and delivering it to an acceptor molecule or a specific location. |
|
•
•
•
•
•
|
GO Term |
Description: |
Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. |
|
•
•
•
•
•
|
GO Term |
Description: |
Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. |
|
•
•
•
•
•
|
GO Term |
Description: |
The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
|
•
•
•
•
•
|
GO Term |
Description: |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
oxygen free radical metabolic process |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
positive regulation of oxygen metabolism |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
negative regulation of oxygen metabolism |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
response to lowered oxygen tension |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
detection of reduced oxygen levels |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
response to oxygen molecular entity |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
removal of oxygen free radicals |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
response to increased oxygen tension |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
response to raised oxygen levels |
Type: |
synonym |
|
•
•
•
•
•
|
Ontology Term Synonym |
Name: |
response to lowered oxygen levels |
Type: |
synonym |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiger L |
Title: |
Trematode hemoglobins show exceptionally high oxygen affinity. |
Year: |
1998 |
Journal: |
Biophys J |
Volume: |
75 |
Pages: |
990-8 |
|
•
•
•
•
•
|
Gene |
Length: |
5248
|
Chromosome Location: |
Chr2: 16598072-16603319 |
Organism . Short Name: |
A. thaliana |
TAIR Computational Description: |
delta1-pyrroline-5-carboxylate synthase 1;(source:Araport11) |
TAIR Curator Summary: |
encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. encodes a delta1-pyrroline-5-carboxylate synthase that catalyzes the rate-limiting enzyme in the biosynthesis of proline. Gene is expressed in reproductive organs and tissues under non-stress conditions but in the whole plant under water-limiting condition. Expression is also induced by abscisic acid and salt stress in a light-dependent manner. P5CS1 appears to be involved in salt stress responses related to proline accumulation, including protection from reactive oxidative species. P5CS1 appears to be present in different cells and/or different subcellular locations from P5CS2 in a tissue-dependent manner. |
TAIR Short Description: |
delta1-pyrroline-5-carboxylate synthase 1 |
TAIR Aliases: |
ATP5CS, P5CS1 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Publication |
First Author: |
McBride JD |
Title: |
Peptide mimics of the Bowman-Birk inhibitor reactive site loop. |
Year: |
2002 |
Journal: |
Biopolymers |
Volume: |
66 |
Pages: |
79-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo CJ |
Title: |
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. |
Year: |
2017 |
Journal: |
Cell |
Volume: |
168 |
Pages: |
517-526.e18 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Ontology Term |
Description: |
Protein involved in the transport of oxygen (e.g. hemoglobin and myoglobin) |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
227 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
227 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
296 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
296 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
299 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
299 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
136 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
136 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
178 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
178 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
175 |
Description: |
Abolishes cyanide-resistant oxygen consumption. |
Type: |
mutagenesis site |
End: |
175 |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|
Protein Domain |
|
•
•
•
•
•
|