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Gene : ELO3 A. thaliana

DB identifier  ? AT5G50320 Secondary Identifier  ? locus:2177477
Name  ? ELONGATA 3 Brief Description  radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
TAIR Computational Description  radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein;(source:Araport11)
TAIR Curator Summary  A subunit of Elongator, a histone acetyl transferase complex, consisting of six subunits (ELP1�ELP6), that copurifies with the elongating RNAPII in yeast and humans. Three Arabidopsis thaliana genes, encoding homologs of the yeast Elongator subunits ELP1, ELP3 (histone acetyl transferase), and ELP4 are responsible for the narrow leaf phenotype in elongata mutants and for reduced root growth that results from a decreased cell division rate. Two lines with RNAi constructs directed against HAG3 grow normally and can produce root calli, but have defects in agrobacterium-mediated transformation.
TAIR Short Description  radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein
TAIR Aliases  AtELP3, EAST1, ELO3, ELP3, HAC8, HAG3

8 Gene Rifs

1 Organism

29 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4320  
Location: Chr5:20480626-20484945 reverse strand

Gene models - ELO3 AT5G50320

? Gene models

Transcripts: 1  Exons: 9  Introns: 8 

Overlapping Features

? Genome features that overlap coordinates of this Gene

10 Child Features

1 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
ELP3_ARATH function Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:20398216). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Promotes organ development by modulating cell division rate (PubMed:20080602). Required for auxin distribution or signaling (PubMed:20080602). Required for meristem cell cycle activation at the time of germination (PubMed:23969312). Mediates the establishment of leaf polarity independently of AS2 and the ta-siRNA-related pathway (PubMed:21700721). Indirectly involved in negatively regulating the expression of genes that participate in UV-B responses, such as DNA repair enzymes and enzymes that participate in sunscreen pigment biosynthesis (PubMed:25907565).
ELP3_ARATH pathway tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.
ELP3_ARATH similarity Belongs to the ELP3 family.
ELP3_ARATH subcellular location Localized in euchromatin during interphase.
ELP3_ARATH tissue specificity Expressed in meristematic tissues of in roots, leaves, seedlings, cotyledons, floral buds and shoot apices (PubMed:15894610, PubMed:20080602, PubMed:23969312). Expressed in the shoot meristem and the emerging leaves immediately after germination (PubMed:23969312). In the root, expressed in the transition zone and the upper meristematic zone (PubMed:23969312).

1 Proteins

Function

Interactions

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Expression

eFP Visualization

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Co-expression

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Data Source: ATTED-II
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LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets