Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
PABP2_ARATH | function | Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the cytoplasm, affects both translation and mRNA decay. Stimulates translation by interaction with translation initiation factor eIF4G, a subunit of the cap-binding complex eIF4F, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. During infection with potyvirus TuMV, acts as a potential integral component of the viral replicase complex that could play an important role in the regulation of potyviral RNA-dependent RNA polymerase (RdRp). Binds to uridylated mRNAs and determines the size of uridine extensions (PubMed:26972004). Limits uridine extension by URT1, likely by binding to the oligo(A) tail and preventing URT1 access (PubMed:26972004). |
PABP2_ARATH | similarity | Belongs to the polyadenylate-binding protein type-1 family. |
PABP2_ARATH | subcellular location | In TuMV-infected plants, partially retargeted in cytoplasmic virus-induced vesicles and in the nucleolus. |
PABP2_ARATH | tissue specificity | Expressed in all organs (at the protein level) but under distinct spatial and temporal regulation within each organ. |
Function
Gene Ontology
cellular component | |
---|---|
plasma membrane | ECO |
ribonucleoprotein complex | ECO |
nucleus | ECO |
cytoplasm | ECO |
molecular function | |
translation initiation factor activity | ECO |
mRNA binding | ECO |
biological process | |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | ECO |
regulation of translational initiation | ECO |
translational initiation | ECO |
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | ECO |
regulation of nuclear-transcribed mRNA poly(A) tail shortening | ECO |
Interactions
Interaction Network
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