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Gene : MLH1 A. thaliana

DB identifier  ? AT4G09140 Secondary Identifier  ? locus:2122388
Name  ? MUTL-homologue 1 Brief Description  MUTL-homologue 1
TAIR Computational Description  MUTL-homologue 1;(source:Araport11)
TAIR Curator Summary  Encodes a protein with similarity to Mut1 DNA mismatch repair protein, from E.coli. The protein is expressed during prophase I of meiosis, colocalizes with MLH3 throughout pachytene and is dependent on MLH3 for proper localization.
TAIR Short Description  MUTL-homologue 1
TAIR Aliases  ATMLH1, MLH1

1 Gene Rifs

1 Organism

17 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4125  
Location: Chr4:5816942-5821066 reverse strand

Gene models - MLH1 AT4G09140

? Gene models

Transcripts: 2  Exons: 31  Introns: 29 

Overlapping Features

? Genome features that overlap coordinates of this Gene

19 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
MLH1_ARATH developmental stage Expressed during prophase I of meiosis: detected from pachytene to diakinesis stages.
MLH1_ARATH function Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.
A0A1P8B4Y5_ARATH MLH1_ARATH similarity Belongs to the DNA mismatch repair MutL/HexB family.
MLH1_ARATH tissue specificity Ubiquitous.

2 Proteins

Function

Gene Ontology

cellular component
chromatin  ? ECO  
mismatch repair complex  ? ECO  
nucleus  ? ECO  
molecular function
ATP binding  ? ECO  
ATP hydrolysis activity  ? ECO  
ATP-dependent DNA damage sensor activity  ? ECO  
mismatched DNA binding  ? ECO  
biological process
pollen development  ? ECO  
mitotic recombination  ? ECO  
mismatch repair  ? ECO  
fruit development  ? ECO  
seed germination  ? ECO  
seed development  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets