Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
MLH1_ARATH | developmental stage | Expressed during prophase I of meiosis: detected from pachytene to diakinesis stages. |
MLH1_ARATH | function | Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates. |
A0A1P8B4Y5_ARATH MLH1_ARATH | similarity | Belongs to the DNA mismatch repair MutL/HexB family. |
MLH1_ARATH | tissue specificity | Ubiquitous. |
Function
Gene Ontology
cellular component | |
---|---|
chromatin | ECO |
mismatch repair complex | ECO |
nucleus | ECO |
molecular function | |
ATP binding | ECO |
ATP hydrolysis activity | ECO |
ATP-dependent DNA damage sensor activity | ECO |
mismatched DNA binding | ECO |
biological process | |
pollen development | ECO |
mitotic recombination | ECO |
mismatch repair | ECO |
fruit development | ECO |
seed germination | ECO |
seed development | ECO |
Interactions
Interaction Network
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