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Gene : TPC1 A. thaliana

DB identifier  ? AT4G03560 Secondary Identifier  ? locus:2128716
Name  ? two-pore channel 1 Brief Description  two-pore channel 1
TAIR Computational Description  two-pore channel 1;(source:Araport11)
TAIR Curator Summary  Encodes a depolarization-activated Ca(2+) channel. Anti-sense experiments with this gene as well as Sucrose-H(+) symporters and complementation of yeast sucrose uptake mutant cch1 suggest that this protein mediates a voltage-activated Ca(2+ )influx. Mutants lack detectable SV channel activity suggesting TPC1 is essential component of the SV channel. Patch clamp analysis of loss of function mutation indicates TPC1 does not affect Ca2+ signaling in response to abiotic and biotic stress.
TAIR Short Description  two-pore channel 1
TAIR Aliases  ATCCH1, ATTPC1, FOU2, TPC1

23 Gene Rifs

1 Organism

53 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 6052  
Location: Chr4:1579929-1585980

Gene models - TPC1 AT4G03560

? Gene models

Transcripts: 1  Exons: 23  Introns: 22 

Overlapping Features

? Genome features that overlap coordinates of this Gene

24 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
TPC1_ARATH function Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.
TPC1_ARATH similarity Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
TPC1_ARATH tissue specificity Ubiquitously expressed.

1 Proteins

Function

Gene Ontology

cellular component
plant-type vacuole  ? ECO  
Golgi apparatus  ? ECO  
cytosol  ? ECO  
plasma membrane  ? ECO  
vacuolar membrane  ? ECO  
monoatomic ion channel complex  ? ECO  
vacuole  ? ECO  
molecular function
identical protein binding  ? ECO  
voltage-gated calcium channel activity  ? ECO  
calcium ion binding  ? ECO  
biological process
calcium-mediated signaling  ? ECO  
regulation of jasmonic acid biosynthetic process  ? ECO  
calcium ion transport  ? ECO  
regulation of stomatal movement  ? ECO  
seed germination  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets