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Gene : TIR1 A. thaliana

DB identifier  ? AT3G62980 Secondary Identifier  ? locus:2099237
Name  ? TRANSPORT INHIBITOR RESPONSE 1 Brief Description  F-box/RNI-like superfamily protein
TAIR Computational Description  F-box/RNI-like superfamily protein;(source:Araport11)
TAIR Curator Summary  Encodes an auxin receptor that mediates auxin-regulated transcription. It contains leucine-rich repeats and an F-box and interacts with ASK1, ASK2 and AtCUL1 to form SCF-TIR1, an SCF ubiquitin ligase complex. Related to yeast Grr1p and human SKP2 proteins, involved in ubiquitin-mediated processes. Required for normal response to auxin and repressed in response to flagellin. As part of the SCF complex and in the presence of auxin, TIR1 interacts with Aux/IAA transcriptional repressor proteins and mediates their degradation. Mutations in TIR1 block auxin stimulation of flavonoid synthesis.
TAIR Short Description  F-box/RNI-like superfamily protein
TAIR Aliases  AtTIR1, TIR1

32 Gene Rifs

1 Organism

137 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3566  
Location: Chr3:23273065-23276630 reverse strand

Gene models - TIR1 AT3G62980

? Gene models

Transcripts: 1  Exons: 3  Introns: 2 

Overlapping Features

? Genome features that overlap coordinates of this Gene

4 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
TIR1_ARATH developmental stage Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues.
TIR1_ARATH function Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.
TIR1_ARATH pathway Protein modification; protein ubiquitination.
TIR1_ARATH tissue specificity Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues.

1 Proteins

Function

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets