Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
LOH1_ARATH | function | Essential for plant growth, promotes cell division in root meristems (PubMed:21666002, PubMed:21883234, PubMed:26276842). Catalyzes the biosynthesis of ceramide sphingolipids with C(16) to C(28) fatty acids, structural membrane lipids involved in membrane trafficking (e.g. early endosomes) and cell polarity (e.g. polar auxin transport related proteins); mostly active with t18:0 and saturated very long saturated fatty acids (C24:0 and C26:0), such as long-chain base (LCB) phytosphingosine (t18:0), lignoceroyl- and hexacosanoyl-CoAs (PubMed:21666002, PubMed:21883234, PubMed:26276842, PubMed:26635357). Mediates resistance to sphinganine-analog mycotoxins (SAMs, e.g. fumonisin B(1)) by restoring the sphingolipid biosynthesis (By similarity). Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity). May prevent precocious cell death by delaying PR1 accumulation during aging (PubMed:21883234). Contributes to hypoxic conditions tolerance (e.g. submergences), especially in the dark, by promoting the formation of very-long-chain (VLC) ceramide species (22:1, 24:1 and 26:1) and of VLC unsaturated ceramides, which are modulating CTR1-mediated ethylene signaling leading to endoplasmic reticulum (ER)-to-nucleus translocation of EIN2 and EIN3 (PubMed:25822663). |
LOH1_ARATH | pathway | Sphingolipid metabolism. |
LOH1_ARATH | tissue specificity | Expressed ubiquitously at high levels (PubMed:21883234). Not observed in pollen (PubMed:25794895). |
Function
Gene Ontology
cellular component | |
---|---|
endoplasmic reticulum | ECO |
endoplasmic reticulum membrane | ECO |
Golgi apparatus | ECO |
plasma membrane | ECO |
molecular function | |
sphingosine N-acyltransferase activity | ECO |
biological process | |
endomembrane system organization | ECO |
regulation of auxin polar transport | ECO |
ceramide biosynthetic process | ECO |
sphingolipid metabolic process | ECO |
very long-chain fatty acid biosynthetic process | ECO |