Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
CERK1_ARATH | function | Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI). Mediates chitin-induced phosphorylation of PBL27 (PubMed:24750441). |
CERK1_ARATH | similarity | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
CERK1_ARATH | tissue specificity | Expressed ubiquitously, with lowest expression in pollen. |
Function
Gene Ontology
cellular component | |
---|---|
plasma membrane | ECO |
molecular function | |
ATP binding | ECO |
histone H2AS1 kinase activity | ECO |
protein serine kinase activity | ECO |
transmembrane receptor protein kinase activity | ECO |
identical protein binding | ECO |
protein kinase activity | ECO |
kinase activity | ECO |
chitin binding | ECO |
chitosan binding | ECO |
protein serine/threonine kinase activity | ECO |
protein homodimerization activity | ECO |
biological process | |
cellular response to chitin | ECO |
detection of peptidoglycan | ECO |
cell surface pattern recognition receptor signaling pathway | ECO |
innate immune response | ECO |
cellular response to molecule of bacterial origin | ECO |
protein autophosphorylation | ECO |
protein phosphorylation | ECO |
response to chitin | ECO |
defense response to bacterium | ECO |
intracellular signal transduction | ECO |
defense response to fungus | ECO |
detection of molecule of fungal origin | ECO |
Interactions
Interaction Network
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