Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
MSH2_ARATH | function | Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway. |
MSH2_ARATH | similarity | Belongs to the DNA mismatch repair MutS family. |
Function
Gene Ontology
cellular component | |
---|---|
plasma membrane | ECO |
nucleus | ECO |
molecular function | |
ATP binding | ECO |
ATP-dependent DNA damage sensor activity | ECO |
damaged DNA binding | ECO |
mismatched DNA binding | ECO |
biological process | |
pyrimidine dimer repair | ECO |
mismatch repair | ECO |
negative regulation of reciprocal meiotic recombination | ECO |
Interactions
Interaction Network
Show the following interaction types:
Reset view
Show in table format
Export graph
- Click on a gene to get more info about it.