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Gene : MSH2 A. thaliana

DB identifier  ? AT3G18524 Secondary Identifier  ? locus:2095097
Name  ? MUTS homolog 2 Brief Description  MUTS homolog 2
TAIR Computational Description  MUTS homolog 2;(source:Araport11)
TAIR Curator Summary  Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.
TAIR Short Description  MUTS homolog 2
TAIR Aliases  ATMSH2, MSH2

5 Gene Rifs

1 Organism

23 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4745  
Location: Chr3:6367941-6372685 reverse strand

Gene models - MSH2 AT3G18524

? Gene models

Transcripts: 1  Exons: 13  Introns: 12 

Overlapping Features

? Genome features that overlap coordinates of this Gene

14 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
MSH2_ARATH function Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
MSH2_ARATH similarity Belongs to the DNA mismatch repair MutS family.

1 Proteins

Function

Gene Ontology

cellular component
plasma membrane  ? ECO  
nucleus  ? ECO  
molecular function
ATP binding  ? ECO  
ATP-dependent DNA damage sensor activity  ? ECO  
damaged DNA binding  ? ECO  
mismatched DNA binding  ? ECO  
biological process
pyrimidine dimer repair  ? ECO  
mismatch repair  ? ECO  
negative regulation of reciprocal meiotic recombination  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets