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Gene : TMM A. thaliana

DB identifier	AT1G80080	Secondary Identifier	locus:2016319
Name	TOO MANY MOUTHS	Brief Description	Leucine-rich repeat (LRR) family protein

TAIR Computational Description	Leucine-rich repeat (LRR) family protein;(source:Araport11)
TAIR Curator Summary	Encodes a transmembrane leucine-repeat containing receptor-like protein that is expressed in proliferative postprotodermal cells. Recessive mutation leads to disruption of asymmetric cell division during stomata development. Its transcript levels change after inducing MUTE expression in a mute background.
TAIR Short Description	Leucine-rich repeat (LRR) family protein
TAIR Aliases	AtRLP17, TMM

6 Gene Rifs

1 Organism

63 Publications

0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	1831
Location:	Chr1:30127819-30129649 reverse strand

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2 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

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Curated comments from UniProt

Type	Comment	Proteins
TMM_ARATH	developmental stage	Expressed in the stomatal precursor cells and in immature stomata (PubMed:19513241). Decreases as leaves matured and no expression in fully expanded leaves (PubMed:18979118).
TMM_ARATH	function	Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC) (PubMed:11090210, PubMed:12040198, PubMed:18979118). Positively regulates CAPRICE (CPC) expression in differentiating stomaless-forming cell files (PubMed:19513241). Forms constitutive complexes with ERECTA and ERL1 involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146). Modulates the activity of the ligand-receptor pairs EPF2-ERECTA and EPF1-ERL1 in stomatal development (PubMed:16002616, PubMed:22241782). Functions in a combinatorial specific manner with the ERECTA-family (ERf) receptor kinases in the regulation of the immune response (PubMed:27446127).
TMM_ARATH	similarity	Belongs to the RLP family.
TMM_ARATH	tissue specificity	In epidermal cells of developing shoots and leaves, but not in roots. Expressed in the stomatal cell lineage in the developing epidermis. Accumulates strongly in meristemoid mother cells (MMC) and meristemoids, somewhat less in meristemoid sister cells (stomatal-lineage ground cells, SLGC), and is barely detected in pavement cells (PubMed:26203655).

1 Proteins

Function

Gene Ontology

cellular component
plasma membrane	ECO
membrane	ECO
molecular function
receptor serine/threonine kinase binding	ECO
peptide binding	ECO
biological process
cellular response to abscisic acid stimulus	ECO
innate immune response	ECO
regulation of antifungal innate immune response	ECO
response to abscisic acid	ECO
stomatal complex patterning	ECO
asymmetric cell division	ECO
trichome morphogenesis	ECO
defense response to fungus	ECO
stomatal complex formation	ECO

Interactions

Interaction Network

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Expression

Data Source:

BAR Webservices

Querying ATTED Service... Data Source: ATTED-II

Homology

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9 Data Sets

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