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Gene : AN A. thaliana

DB identifier	AT1G01510	Secondary Identifier	locus:2025376
Name	ANGUSTIFOLIA	Brief Description	NAD(P)-binding Rossmann-fold superfamily protein

TAIR Computational Description	NAD(P)-binding Rossmann-fold superfamily protein;(source:Araport11)
TAIR Curator Summary	Encodes a homolog of human CtBP. Mutant has longer and thicker leaves than wild type. Involved in controlling polar cell expansion in the leaf width direction. It has been shown to localize to cytosolic stress granules and is involved in their formation.
TAIR Short Description	NAD(P)-binding Rossmann-fold superfamily protein
TAIR Aliases	AN, DOQ

8 Gene Rifs

1 Organism

31 Publications

0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	3328
Location:	Chr1:187145-190472

Genes

DB identifier	Secondary Identifier	Symbol	Name	Length	Chromosome Location	Organism . Short Name	TAIR Computational Description	TAIR Curator Summary	TAIR Short Description	TAIR Aliases
AT1G01520	locus:2025411	ASG4	ALTERED SEED GERMINATION 4	2029	Chr1: 190408-192436	A. thaliana	Homeodomain-like superfamily protein;(source:Araport11)	RVE3 is one of eleven homologous MYB-like transcription factors in Arabidopsis and a member of the RVE8 clade. Plays a minor role in clock regulation.	Homeodomain-like superfamily protein	ASG4, REV3

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8 Child Features

1 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

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Curated comments from UniProt

Type	Comment	Proteins
CTBP_ARATH	function	Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Required for cortical microtubules (MTs) arrangement that confers cell shape. Cooperatively with IPGA1, negatively regulates cortical microtubules (CMTs) organization in response to mechanical stress and modulates pavement cells morphogenesis leading to puzzle shape, probably in an AAA1/KTN1-dependent manner (PubMed:35975703). Regulates the width of leaves by controlling the polar elongation of leaf cells. Involved in the regulation of trichome branching. Seems to not be able to regulate gene transcription. Regulates epidermal cell divisions and elongation in a non-cell-autonomous manner (regulated by subepidermal cells), but regulates epidermal cell polarity, shape, trichome branching and elongation in a cell-autonomous manner. Negatively regulates growth in the petiole elongation. Prevents lipid peroxidation as a result of abiotic stress response. Is involved in the SUB-dependent signaling mechanism and may act in a membrane trafficking event around the trans-Golgi network.
CTBP_ARATH	similarity	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Plant AN subfamily.
CTBP_ARATH	subcellular location	Was thought initially to be located in nucleus (PubMed:11889033, PubMed:11889034) but the large dot-like structures are now believed to represent non-physiological aggregates (PubMed:11889033, PubMed:11889034). In root cells, cytoplasmic polarized localization near cell edges, at the vicinity of SOKs proteins (PubMed:32004461). Associates with membranes in puncta in embryos (PubMed:32004461).
CTBP_ARATH	tissue specificity	Expressed in cotyledons, leaves, roots, stems and floral buds.

1 Proteins

Function

Gene Ontology

cellular component
trans-Golgi network	ECO
cytoplasmic stress granule	ECO
cytosol	ECO
microtubule	ECO
molecular function
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ECO
identical protein binding	ECO
transcription corepressor activity	ECO
kinase binding	ECO
NAD binding	ECO
protein homodimerization activity	ECO
biological process
regulation of epidermal cell division	ECO
fruit morphogenesis	ECO
nuclear migration	ECO
response to salt stress	ECO
response to osmotic stress	ECO
regulation of trichome morphogenesis	ECO
inductive cell-cell signaling	ECO
microtubule cytoskeleton organization	ECO
trichome branching	ECO
regulation of epidermal cell differentiation	ECO
monopolar cell growth	ECO
cotyledon morphogenesis	ECO
leaf morphogenesis	ECO
regulation of cell shape	ECO
stress granule assembly	ECO
floral organ morphogenesis	ECO

Interactions

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Expression

Data Source:

BAR Webservices

Querying ATTED Service... Data Source: ATTED-II

Homology

0 Homologues

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9 Data Sets

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