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Gene : HSD1 A. thaliana

DB identifier	AT5G50600	Secondary Identifier	locus:2159747
Name	hydroxysteroid dehydrogenase 1	Brief Description	hydroxysteroid dehydrogenase 1

TAIR Computational Description	hydroxysteroid dehydrogenase 1;(source:Araport11)
TAIR Curator Summary	Encodes a hydroxysteroid dehydrogenase shown to act as a NADP+-dependent 11β-,17β-hydroxysteroid dehydrogenase/17β-ketosteroid reductase called HSD1. Two copies of HSD1 (At5g50600 and At5g50700) exist in the Arabidopsis genome as a result of an exact 33-kb duplication on chromosome 5 encompassing seven genes. There are five homologs of HSD1 in Arabidopsis (HSD2-At3g47350, HSD3-At3g47360, HSD4-At5g50590, HSD4-At5g50690 and HSD6-At5g50770; HSD4 has two copies due to the same gene duplication event occurred to HSD1) (Plant Cell Physiology 50:1463). At5g50690 is also named as HSD7 (Plant Physiology 145:87). HSD1 is identified from the proteome of oil bodies from mature seeds. Transcription of HSD1 is specifically and highly induced in oil-accumulating tissues of mature seeds; transcript disappears during germination. To date, the endogenous substrates of this enzyme are not known.
TAIR Short Description	hydroxysteroid dehydrogenase 1
TAIR Aliases	ATHSD1, HSD1

2 Gene Rifs

1 Organism

17 Publications

0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	2236
Location:	Chr5:20589702-20591937 reverse strand

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7 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

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Curated comments from UniProt

Type	Comment	Proteins
HSD1A_ARATH	developmental stage	Firstly detected during early seed maturation, at 9 days after anthesis (DAA), peaking at 18 DAA, before falling sharply during late maturation.
HSD1A_ARATH	function	Catalyzes 11-beta, 17-beta-hydroxysteroid and reduces 17-beta-ketosteroids. Involved in regulating plant growth and development, probably promoting or mediating brassinosteroid effects. Plays a role during seed maturation.
HSD1A_ARATH	similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family.
HSD1A_ARATH	tissue specificity	Expressed in the above-ground part of seedlings, especially in the vascular tissues. Also detected in the buds and silique pedicels. Highly induced in oil-accumulating tissues of maturing seeds.

1 Proteins

Function

Gene Ontology

cellular component
cytosol	ECO
lipid droplet	ECO
membrane	ECO
molecular function
cortisol dehydrogenase activity	ECO
17-beta-hydroxysteroid dehydrogenase (NADP+) activity	ECO
estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ECO
biological process
steroid metabolic process	ECO
steroid biosynthetic process	ECO

Interactions

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Expression

Data Source:

BAR Webservices

Querying ATTED Service... Data Source: ATTED-II

Homology

0 Homologues

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9 Data Sets

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