Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
ORTH1_ARATH | function | E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e.g. UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. |
ORTH1_ARATH | pathway | Protein modification; protein ubiquitination. |
ORTH1_ARATH | subcellular location | Broadly distributed in the nucleus and enriched in the heterochromatic chromocenters. |
ORTH1_ARATH | tissue specificity | Expressed in inflorescences and leaves. |
Function
Gene Ontology
cellular component | |
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nucleus
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ECO |
molecular function | |
methyl-CpNpG binding
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ECO |
histone binding
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ECO |
methyl-CpNpN binding
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ECO |
ubiquitin-protein transferase activity
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ECO |
methyl-CpG binding
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ECO |
metal ion binding
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ECO |
biological process | |
protein ubiquitination
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ECO |
vegetative to reproductive phase transition of meristem
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ECO |
negative regulation of gene expression via chromosomal CpG island methylation
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ECO |
Interactions
Interaction Network
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