Genomics
Genome feature
| Region: |
gene
|
Length: |
5977
 |
| Location: | Chr5:787428-793404 | ||
Overlapping Features Displayer
Proteins
Curated comments from UniProt
| Type | Comment | Proteins |
|---|---|---|
| EIN2_ARATH | function | Central factor in signaling pathways regulated by ethylene (ET) and involved in various processes including development, plant defense, senescence, nucleotide sugar flux, and tropisms (PubMed:27694846, PubMed:28874528). Necessary for ethylene-mediated gene regulation, and for the induction of some genes by ozone. Acts downstream of ET receptors, and upstream of ethylene regulated transcription factors. Required for cytokinin-mediated processes. Seems to be implicated in cross-talk between ET, jasmonate and other pathways. Probably not involved in iron uptake (PubMed:10381874, PubMed:12953109, PubMed:14973160, PubMed:15010611, PubMed:15272873, PubMed:7770519, PubMed:9351240). Has a short half-life and undergoes rapid proteasome-mediated turnover in the absence of ethylene (PubMed:19196655). Required for ethylene-induced EIN3 stabilization via proteasomal degradation of EBF1/EBF2 proteins (PubMed:20647342). Regulates the leaf senescence induced by methyl jasmonate, ethylene and abscisic acid (PubMed:15010611, Ref.17). Required during salt stress to confer resistance (PubMed:21631530). |
| EIN2_ARATH | function | Trafficking signal inducing ethylene response. The nuclear localization is both necessary and sufficient to activate EIN3-mediated transcription and ethylene responses (PubMed:23070300). Involved in ethylene (ET)-mediated signaling pathways by triggering histone acetylation of H3K14 and H3K23 in an ENAP1-dependent manner, thus influencing the expression of ethylene-responsive genes (PubMed:27694846, PubMed:28874528). Necessary and sufficient for 3'-UTR-mediated translational repression of EBF1 and EBF2 mRNAs. Ethylene induces EIN2-CEND to associate with 3' UTRs in cytoplasmic foci and target EBF1/2 mRNAs to cytoplasmic processing-body (P-body) (PubMed:26496607, PubMed:26496608). MPK6 regulates the cleavage and nuclear translocation of EIN2-CEND under methyl jasmonate treatment (PubMed:26507893). Required for EIN3 accumulation (PubMed:26507893). |
| EIN2_ARATH | similarity | Belongs to the NRAMP (TC 2.A.55) family. |
| EIN2_ARATH | subcellular location | Perception of ethylene or methyl jasmonate leads to proteolytic cleavage allowing the C-terminal domain to localize to the nucleus while the N-terminus remains at the endoplasmic reticulum membrane. Apart from nuclear localization, some association with endoplasmic membranes and some speckles are also observed in the cytoplasm. During hypoxia (e.g. submergences), translocates from endoplasmic reticulum (ER) to the nucleus via a ceramides-triggered and CTR1-dependent manner (PubMed:25822663). |
| EIN2_ARATH | tissue specificity | Localized to the guard cells after methyl jasmonate treatment. |
