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Gene : FKBP53 A. thaliana

DB identifier  ? AT4G25340 Secondary Identifier  ? locus:2138029
Name  ? FK506 BINDING PROTEIN 53 Brief Description  FK506 BINDING PROTEIN 53
TAIR Computational Description  FK506 BINDING PROTEIN 53;(source:Araport11)
TAIR Curator Summary  Encodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression. The N-terminal nucleoplasmin domain interacts with H2A/H2B and H3/H4 histone oligomers, individually, as well as simultaneously, suggesting two different binding sites for H2A/H2B and H3/H4.
TAIR Short Description  FK506 BINDING PROTEIN 53
TAIR Aliases  ATFKBP53, FKBP53

2 Gene Rifs

1 Organism

13 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3423  
Location: Chr4:12959349-12962771 reverse strand

Gene models - FKBP53 AT4G25340

? Gene models

Transcripts: 2  Exons: 22  Introns: 20 

Overlapping Features

? Genome features that overlap coordinates of this Gene

16 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
FKB53_ARATH function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Histone chaperone possibly involved in H3/H4 deposition to the nucleosome. Associates with 18S rDNA chromatin and negatively regulates the level of its expression.
FKB53_ARATH similarity Belongs to the FKBP-type PPIase family.
FKB53_ARATH tissue specificity Broadly expressed in leaves, flowers, stems and roots. Detected in root apical meristem region and pollen.

2 Proteins

Function

Gene Ontology

cellular component
nucleolus  ? ECO  
nucleus  ? ECO  
molecular function
histone binding  ? ECO  
peptidyl-prolyl cis-trans isomerase activity  ? ECO  
biological process
nucleosome assembly  ? ECO  

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets