Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
ATG4A_ARATH ATG4A_ARATH-2 | function | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins (By similarity). |
A0A1P8B129_ARATH A0A178VZ47_ARATH | function | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins. |
ATG4A_ARATH A0A1P8B129_ARATH ATG4A_ARATH-2 A0A178VZ47_ARATH | similarity | Belongs to the peptidase C54 family. |
ATG4A_ARATH ATG4A_ARATH-2 | tissue specificity | Constitutively expressed. |
Function
Gene Ontology
cellular component | |
---|---|
cytoplasm | ECO |
molecular function | |
endopeptidase activity | ECO |
protein-phosphatidylethanolamide deconjugating activity | ECO |
cysteine-type peptidase activity | ECO |
biological process | |
proteolysis | ECO |
protein transport | ECO |
autophagy | ECO |
Interactions
Interaction Network
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