help  | faq  | software  | BAR
Hide

Oops!

Error: 403

Gene : AT2G44140 A. thaliana

DB identifier  ? AT2G44140 Secondary Identifier  ? locus:2051754
Brief Description  Peptidase family C54 protein
TAIR Computational Description  Peptidase family C54 protein;(source:Araport11)
TAIR Curator Summary  Autophagy protein that cleaves ATG8s.
TAIR Short Description  Peptidase family C54 protein
TAIR Aliases  ATG4A

1 Gene Rifs

1 Organism

9 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4797  
Location: Chr2:18253497-18258293 reverse strand

Gene models - AT2G44140 AT2G44140

? Gene models

Transcripts: 5  Exons: 46  Introns: 41 

Overlapping Features

? Genome features that overlap coordinates of this Gene

23 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
ATG4A_ARATH ATG4A_ARATH-2 function Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins (By similarity).
A0A1P8B129_ARATH A0A178VZ47_ARATH function Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of PE-conjugated ATG8 proteins.
ATG4A_ARATH A0A1P8B129_ARATH ATG4A_ARATH-2 A0A178VZ47_ARATH similarity Belongs to the peptidase C54 family.
ATG4A_ARATH ATG4A_ARATH-2 tissue specificity Constitutively expressed.

4 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
molecular function
endopeptidase activity  ? ECO  
protein-phosphatidylethanolamide deconjugating activity  ? ECO  
cysteine-type peptidase activity  ? ECO  
biological process
proteolysis  ? ECO  
protein transport  ? ECO  
autophagy  ? ECO  

Interactions

Interaction Network

Show the following interaction types:
Reset view
Show in table format
Export graph

Click on a gene to get more info about it.

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets