Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
HESO1_ARATH | function | Uridylates small RNAs to trigger their degradation (PubMed:22464191, PubMed:22464194, PubMed:25928341). Catalyzes the uridylation of 5' fragments produced by AGO1-mediated cleavage of miRNA target RNAs (PubMed:24733911). Acts synergistically with URT1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341). URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405). URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405). URT1 and HESO1 are involved in the uridylation and clearance of RISC-generated 5' mRNA fragments (PubMed:30364210). Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:24733911, PubMed:25928405). |
HESO1_ARATH | similarity | Belongs to the DNA polymerase type-B-like family. |
Function
Gene Ontology
cellular component | |
---|---|
nucleus | ECO |
P-body | ECO |
cytoplasm | ECO |
molecular function | |
RNA uridylyltransferase activity | ECO |
nucleotidyltransferase activity | ECO |
biological process | |
RNA 3' uridylation | ECO |
miRNA catabolic process | ECO |
Interactions
Interaction Network
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