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Gene : HESO1 A. thaliana

DB identifier  ? AT2G39740 Secondary Identifier  ? locus:2063937
Name  ? HEN1 suppressor 1 Brief Description  Nucleotidyltransferase family protein
TAIR Computational Description  Nucleotidyltransferase family protein;(source:Araport11)
TAIR Curator Summary  Encodes HESO1 (HEN1 suppressor 1), a terminal nucleotidyl transferase that uridylates miRNAs and siRNAs at 3′ end. HESO1-mediated 3′ uridylation destabilizes small RNAs in hen1.
TAIR Short Description  Nucleotidyltransferase family protein
TAIR Aliases  HESO1

5 Gene Rifs

1 Organism

13 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 3369  
Location: Chr2:16575752-16579120

Gene models - HESO1 AT2G39740

? Gene models

Transcripts: 3  Exons: 27  Introns: 24 

Overlapping Features

? Genome features that overlap coordinates of this Gene

15 Child Features

1 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
HESO1_ARATH function Uridylates small RNAs to trigger their degradation (PubMed:22464191, PubMed:22464194, PubMed:25928341). Catalyzes the uridylation of 5' fragments produced by AGO1-mediated cleavage of miRNA target RNAs (PubMed:24733911). Acts synergistically with URT1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341). URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405). URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405). URT1 and HESO1 are involved in the uridylation and clearance of RISC-generated 5' mRNA fragments (PubMed:30364210). Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:24733911, PubMed:25928405).
HESO1_ARATH similarity Belongs to the DNA polymerase type-B-like family.

1 Proteins

Function

Gene Ontology

cellular component
nucleus  ? ECO  
P-body  ? ECO  
cytoplasm  ? ECO  
molecular function
RNA uridylyltransferase activity  ? ECO  
nucleotidyltransferase activity  ? ECO  
biological process
RNA 3' uridylation  ? ECO  
miRNA catabolic process  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets