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Gene : GN A. thaliana

DB identifier  ? AT1G13980 Secondary Identifier  ? locus:2035853
Name  ? GNOM Brief Description  sec7 domain-containing protein
TAIR Computational Description  sec7 domain-containing protein;(source:Araport11)
TAIR Curator Summary  Encodes a GDP/GTP exchange factor for small G-proteins of the ADP ribosylation factor (RAF) class, and as regulator of intracellular trafficking. Homologous to Sec7p and YEC2 from yeast. Involved in the specification of apical-basal pattern formation. Essential for cell division, expansion and adhesion. It appears that heteotypic binding between the DCB and C-terminal domains of two GNOM proteins is required for membrane association, however, GNOM appears to exist predominantly as a heterodimer formed through DCB-DCB interactions. BFA inhibits GNOM trafficking and BFA resistant lines are more resistant to cold stress.
TAIR Short Description  sec7 domain-containing protein
TAIR Aliases  112A-2A, EMB30, GN, GNOM, MIZ2, VAN7

22 Gene Rifs

1 Organism

61 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 6192  
Location: Chr1:4788463-4794654

Gene models - GN AT1G13980

? Gene models

Transcripts: 2  Exons: 6  Introns: 4 

Overlapping Features

? Genome features that overlap coordinates of this Gene

8 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
GNOM_ARATH developmental stage Continually expressed in both embryogenesis and postembryonic organ development. Strongly expressed in actively dividing or elongating cells but only weakly or not at all in differentiated tissues other than the vasculature.
GNOM_ARATH function Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting. Acts as the major regulator of endosomal vesicle trafficking but is also involved in the endocytosis process. Could function redundantly with GNL1 in the retrograde Golgi to endoplasmic reticulum trafficking. Regulates vesicle trafficking required for the coordinated polar localization of auxin efflux carriers which in turn determines the direction of auxin flow. Mediates the sorting of PIN1 from endosomal compartments to the basal plasma membrane and the polarization of PIN3 to the bottom side of hypocotyl endodermal cells. Involved in the specification of apical-basal pattern formation in the early embryo and during root formation. Required for correct cell wall organization leading to normal cell adhesion during seedling development. Also plays an essential role in hydrotropism of seedling roots.
GNOM_ARATH subcellular location Soluble and partially membrane-bound.
GNOM_ARATH tissue specificity Stems, leaves, flowers, siliques, floral inflorescence and roots. Expressed in the whole plant (at the protein level).

1 Proteins

Function

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets