| Description | Spore formation by the bacterium Bacillus subtilis is a stress response triggered by nutrient limitation. Two operons are strongly induced at the start of sporulation; one of them is skf (for sporulation killing factor). skf produces a killing factor which, together with a signaling protein, act cooperatively to block sister cells from sporulating and cause them to lyse, providing a source of nutrients to support the sporulation process [ ].The first gene of the skf operon, skfA, encodes a small peptide. SkfA induces the lysis of sibling cells that have not entered the sporulation pathway [ ]. The product of the second gene, skfB, encodes a radical SAM enzyme. SkfB creates a sactipeptide (sulfur-to-α-carbon) crosslink of Cys-4 to Met-12 of the mature form of SkfA. In Paenibacillus larvae subsp larvae B-3650, the Met is replaced by Leu, so the modification must be different. SkfB has 2 4Fe-4S clusters, one in its radical SAM domain () and one in a region that somewhat resembles the SPASM domain ( ) [ ]. | Name | Sporulation killing factor system, radical SAM maturase SkfB |
| Short Name | rSAM_SkfB | Type | Family |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
