| Description | This entry represents a group of tumour necrosis factor receptors predominantly found in chordates, including human tumor necrosis factor receptor superfamily member 19/27/EDAR (TNR19/27/EDAR), which can mediate activation of JNK and NF-kappa-B and may promote caspase-independent cell death.TNR19, also known as TAJ and TROY [ ], activates the RhoA and inhibits neurite outgrowth [, ]. It is involved in the development of the epidermis in human and mice [].TNR27 is a receptor for EDA isoform A2, but not for EDA isoform A1 [ ]. On the contrary, EDAR is a receptor for EDA isoform A1, but not for EDA isoform A2. Mutations in the gene encoding for this protein are associated with certain forms of of ectodermal dysplasia [, ].The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [].Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [ ]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. | Name | Tumor necrosis factor receptor superfamily member 19/27/EDAR |
| Short Name | TNR19/27/EDAR | Type | Family |
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