Description | The large subunit of [NiFe]-hydrogenase, as well as other nickel metalloenzymes, is synthesised as a precursor devoid of the metalloenzyme active site. This precursor then undergoes a complex post-translational maturation process that requires a number of accessory proteins. The hydrogenase expression/formation proteins (HupF/HypC) form a family of small proteins that are hydrogenase precursor-specific chaperones required for this maturation process []. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation [, ].The signature pattern for this entry is 9 residues in length, located at the N terminus; all the proteins matched by this pattern start with a conserved Met-Cys dipeptide. | Name | Hydrogenase assembly chaperone, conserved site |
Short Name | Hydgase_assmbl_chp_CS | Type | Conserved_site |