| Description | The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [ ], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].Kelch-like protein 35 (KLHL35) belongs to the KLHL family [ ]. Its function is not clear. Significant differences in the DNA methylation pattern of the KLHL35 gene have been associated with abdominal aortic aneurysm (AAA) and hepatocellular carcinoma [, ].This entry represents the N-terminal BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain of KLHL35 and similar proteins from vertebrates. | Name | Kelch-like protein 35, BTB/POZ domain |
| Short Name | KLHL35_BTB_POZ_dom | Type | Domain |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
