| Description | SARM1 (sterile alpha and TIR motif-containing protein 1) is a TIR (Toll-interleukin 1 receptor) adaptor that downregulates Toll-like receptor signalling [ , , ]. It plays a role in innate immunity []. It is also an essential mediator of axon degeneration know as Wallerian degeneration [, ]. A specific motif in its TIR domain is responsible for NAD+ loss and injury-induced SARM1 activation [, ]. | Name | Sterile alpha and TIR motif-containing protein 1 |
| Short Name | SARM1 | Type | Family |
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