| Description | This superfamily represents the plant-specific WIYLD domain, named based on the pattern of the most conserved residues [ , ]. This is a ubiquitin-binding domain that adopts a four-helix bundle structure, in contrast to the three-helix bundles of other ubiquitin binding domains. It is found in histone-lysine N-methyltransferase SUVR4 and related proteins SUVR1 and SUVR2. SUVR4 is an active histone methyltransferase with a preference for H3K9me1 [] and ubiquitin binding mediated by this domain facilitates the addition of two methyl groups to monomethylated lysine 9 of histone H3 []. SUVR2 has no histone methyltransferase activity and is involved in transcriptional gene silencing []. SUVR2 forms a complex with SUVR1 and associates with the SNF2-related chromatin-remodeling proteins. No histone methyltransferase activity has been detected for SUVR1 neither []. | Name | WIYLD domain superfamily |
| Short Name | WIYLD_dom_sf | Type | Homologous_superfamily |
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