| Description | Transthyretin (prealbumin) is a thyroid hormone-binding protein that seems to transport thyroxine (T4) from the bloodstream to the brain. It is a protein of about 130 amino acids that assembles as a homotetramer and forms an internal channel that binds thyroxine. In humans, transthyretin is mainly synthesised in the brain choroid plexus; variants of the protein are associated with distinct forms of amyloidosis.The sequence of transthyretin is highly conserved in vertebrates. A number of uncharacterised proteins also belong to this family:Escherichia coli hypothetical protein YedX.Bacillus subtilis hypothetical protein YunM.Caenorhabditis elegans hypothetical protein R09H10.3.Caenorhabditis elegans hypothetical protein ZK697.8.The signature pattern in this entry is located in the N-terminal extremity and starts with a lysine known to be involved in binding thyroxine binding. | Name | Transthyretin, thyroxine binding site |
| Short Name | Thyroxine_BS | Type | Binding_site |
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