| Description | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ , ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.Glycoside hydrolase family 4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase ( ); 6-phospho-alpha-glucosidase ( ); alpha-galactosidase ( ). These enzymes require NAD and a divalent ion for their activity and are proteins of about 50kDa; e.g. 6-phospho-alpha-glucosidase requires both NAD(H) and divalent metal (Mn2+, Fe2+, Co2+, or Ni2+) for activity [ ]. The signature pattern is located to a conserved region located in the central section. This region does not contain residues directly shown to be important for the catalytic activity. | Name | Glycoside hydrolase, family 4, conserved site |
| Short Name | GlycHydrolase_4_CS | Type | Conserved_site |
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