| Description | This entry represents a STING (STimulator of INterferon Gene) sensor domain found in certain prokaryotic nucleotide-activated effector conflict systems, like the CBASS (cyclic oligonucleotide-based antiphage signaling system) which provides immunity against bacteriophage. Binding to a nucleotide activates fused effector proteins in conflict response against invasive elements.This domain is found in CD-NTase-associated protein 12 and 13, which bind c-di-GMP and 3'-3'-cGAMP, cyclic nucleotides synthesized by the CD-NTase protein in response to infection that serve as specific second messenger signals to activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection [ ]. Certain versions in prokaryotes may additionally regulate bacterial ion channels. This domain has been transferred to eukaryotes on multiple occasions, and representatives observed are in animal-choanoflagellate, haptophyte/stramenopile, and fungal lineages [].The crystal structure of this domain in from Prevotella corporis shows an α/β fold with a central five-stranded β-sheet surrounded by five α-helices and a β-ribbon [ ]. | Name | Prokaryotic STING domain |
| Short Name | Prok_STING | Type | Domain |
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