| Description | Corticotropin-releasing factor (CRF) (corticoliberin) [ ] is a hormone from the hypothalamus that regulates the release of corticotropin (ACTH) from the pituitary gland. CRF is evolutionary related to a number of other active peptides which are listed below.Urocortin (Ucn) [ ], a brain mammalian peptide with corticotropin-releasing factor activity.Urotensin 1 from the urophysis of fish. Like CRF and Ucn, it acts in ACTH secretion.Sauvagine from frog skin, a peptide with a potent hypotensive action that elicits a diuretic effect.Diuretic hormone (DH) (or diuretic peptide (DP) from a variety of insects. DH is involved in the regulation of fluid secretion [ ].All these hormones are peptides of about 40 amino acid residues which are C-terminally amidated and processed from a larger precursor protein. This signature is a pattern of conserved residues, running from position 4 to 19 in these peptides. | Name | Corticotropin-releasing factor conserved site |
| Short Name | Corticotropin-releasing_fac_CS | Type | Conserved_site |
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