| Description | This subset of the radical-SAM domain includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centred radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, , ) and the anaerobic ribonucleotide reductase activating enzyme ( ). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA, [ ]), benzylsuccinate synthase (BssD, []), gycerol dehydratase (DhaB2, []), trans-4-hydroxy-L-proline dehydratase (pflE, []) as well as enzymes annotated in Escherichia coli as activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterisation and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain, which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines. | Name | Organic radical enzyme activase |
| Short Name | Organic_radical_activase | Type | Family |
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