| Description | This entry represents the adenine-specific methyltransferase PglX, which specifically methylates the adenine in the fifth position of the 5'-TAGGAG-3' region in genomic DNA but not in phage DNA upon infection [ , ]. It is associated with BREX (bacteriophage exclusion) type 1 systems [], which provides immunity against bacteriophage. It allows phage adsorption but blocks phage DNA replication [, ]. The methylation on non-palindromic TAGGAG motifs in the bacterial genome guides self/non-self discrimination and is essential for the defensive function of the BREX system. Unlike restriction-modification systems, phage DNA does not appear to be cleaved or degraded by BREX. | Name | Adenine-specific DNA-methyltransferase PglX |
| Short Name | BREX_1_PglX | Type | Family |
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