| Description | The epithelial membrane proteins (EMP-1, -2 and -3), peripheral myelin protein 22 (PMP22), and lens fibre membrane intrinsic protein (LMIP) comprise a protein family on the basis of sequence and structural similarities [ ]. Each family member is a small hydrophobic membrane glycoprotein, ~160-170 amino acids in length, and shares a common predicted transmembrane (TM) topology of 4 TM domains, with intracellular N- and C-termini [].A role for the EMP family members in the control of cell growth has been suggested [ ]. EMP-1 is expressed at high levels in proliferating cells, and at reduced levels in cells undergoing growth arrest []. In contrast, PMP22, which is co-expressed with EMP-1 in a range of tissues, displays an inverse pattern of regulation, with high levels of expression in cultured cells undergoing growth arrest []. It has therefore been proposed that these proteins may have reciprocal functions in the control of cell quiescence and proliferation.EMP-3, previously termed YMP, was identified by expressed sequence tag (EST) database searching, pursuing sequences similar to EMP-1 [ ]. Mouse, human and rat isoforms have been cloned. EMP-3 is expressed in a range of tissues, including peripheral blood leukocytes, ovary and intestine. Although its function has not been elucidated, it has been postulated that EMP-3 may be involved in the regulation of cell proliferation on the basis of its sequence similarity to EMP-1 []. | Name | Epithelial membrane protein EMP-3 |
| Short Name | EMP_3 | Type | Family |
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