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Gene : BZIP17 A. thaliana

DB identifier	AT2G40950	Secondary Identifier	locus:2058510
Brief Description	Basic-leucine zipper (bZIP) transcription factor family protein

TAIR Computational Description	Basic-leucine zipper (bZIP) transcription factor family protein;(source:Araport11)
TAIR Curator Summary	bZIP17 appears to regulate transcription as part of a salt and osmotic stress response. zip17 mutants show enhanced inhibition of primary root elongation in response to NaCl. Several salt-responsive genes, such as ATHB-7 show a reduced transcriptional response to a salt treatment in zip17 mutant seedlings. myc:bZIP17 undergoes proteolytic processing in salt-treated wild type seedlings, but not in s1p-3 (subtilase) mutants and there is also evidence for S1P-mediated cleavage of bZIP17 in vitro. In addition, an mGFP:bZIP17 protein moves from the ER to the nucleus following salt treatment. It is cleaved by S2P to allow translocation to the nucleus.
TAIR Short Description	Basic-leucine zipper (bZIP) transcription factor family protein
TAIR Aliases	BZIP17

6 Gene Rifs

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1 Organism

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27 Publications

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0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	2992
Location:	Chr2:17087565-17090556 reverse strand

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3 Child Features

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1 Cross References

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1 Downstream Intergenic Region

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0 Located Features

1 Upstream Intergenic Region

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Proteins

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Curated comments from UniProt

Type	Comment	Proteins
BZP17_ARATH	function	Transcriptional activator involved in salt and osmotic stress responses. Functions as a stress sensor and transducer in a signaling pathway that resembles an ER stress response. Following salt stress, BZIP17 is cleaved by SBT6.1 (S1P) and S2P at the C-terminus and the N-terminal bZIP component is translocated to the nucleus, where it activates the expression of salt stress response genes (PubMed:17662035). Functions as a stress sensor and transducer in ER stress signaling pathway. ER stress induces proteolysis of BZIP17 by SBT6.1 (S1P) and S2P, and the N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones, as well as protein involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth (PubMed:20876872).
BZP17_ARATH	similarity	Belongs to the bZIP family.
BZP17_ARATH	subcellular location	Translocates to the nucleus following salt treatment, heat shock or tunicamycin treatment (ER stress) (PubMed:17662035, PubMed:20876872). Relocation of BZIP17 from ER to the nucleus occurs through the Golgi and is S2P-dependent (PubMed:20876872).

1 Proteins

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Function

Gene Ontology

cellular component
endoplasmic reticulum	ECO
endoplasmic reticulum membrane	ECO
nucleus	ECO
Golgi membrane	ECO
molecular function
sequence-specific DNA binding	ECO
DNA-binding transcription factor activity	ECO
transcription cis-regulatory region binding	ECO
biological process
hyperosmotic salinity response	ECO
positive regulation of DNA-templated transcription	ECO
regulation of DNA-templated transcription	ECO

Interactions

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Expression

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BAR Webservices

Querying ATTED Service... Data Source: ATTED-II

Homology

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8 Data Sets

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