| Description | TNF receptor 27 (also known as ectodysplasin A2 receptor (EDA2R) and ectodysplasin receptor, x-linked (XEDAR)) is highly expressed during embryogenesis [ ], and has been implicated in the development of ectodermal appendages, such as hair follicles, teeth and sweat glands []. Although it lacks a death domain, the receptor can nevertheless induce cell death via activation of caspase 8, and may play a role in the induction of apoptosis during embryonic development and adult life [].The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [].Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [ ]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. | Name | Tumour necrosis factor receptor 27 |
| Short Name | TNFR_27 | Type | Family |
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