| Description | This entry represents the RNA recognition motif 1 (RRM1) of RAVER2.Raver-2 is member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family [ ]. It is present in vertebrates and shows high sequence homology to raver-1, a ubiquitously expressed co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. In contrast, raver-2 exerts a distinct spatio-temporal expression pattern during embryogenesis and is mainly limited to differentiated neurons and glia cells. Although it displays nucleo-cytoplasmic shuttling in heterokaryons, raver2 localises to the nucleus in glia cells and neurons. Raver-2 can interact with PTB and may participate in PTB-mediated RNA-processing. However, there is no evidence indicating that raver-2 can bind to cytoplasmic proteins. Raver-2 contains three N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two putative nuclear localisation signals (NLS) at the N- and C-termini, a central leucine-rich region, and a C-terminal region harbouring two [SG][IL]LGxxP motifs. Raver-2 binds to PTB through the SLLGEPP motif only, and binds to RNA through its RRMs [, , , ]. | Name | Ribonucleoprotein PTB-binding 2, RNA recognition motif 1 |
| Short Name | RAVER2_RRM1 | Type | Domain |
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