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Protein Domain : IPR005657

Description  This family contains saliva proteins from haematophagous insects that counteract vertebrate host haemostasis events such as coagulation, vasoconstriction and platelet aggregation []. These include:Triabin, a serine-protease inhibitor with a calycin fold [ ]. It forms a non-covalent complex with thrombin at a molecular ratio of 1:1, and inhibits thrombin-induced platelet aggregation.Procalin is the major allergen of Triatoma protracta saliva [ ].Triplatin, an inhibitor of platelet agregation and vasoconstriction through binding to distinct eicosanoids involved in inflammation that has a role in inhibiting host innate immunity [ , ].Pallidipin, likely to fuction by a mechanism similar to that of triplatin [ ].Members of this family belong to MEROPS proteinase inhibitor family I59, clan IZ. Name  Triabin/Procalin
Short Name  Triabi/Procalin Type  Family
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6 Publications

Genomics

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