| Description | This entry represents a conserved signature pattern located in the N-terminal domain of galactokinases.Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [ , ]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults []. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein []. | Name | Galactokinase, conserved site |
| Short Name | Galactokinase_CS | Type | Conserved_site |
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